There is some recent evidence that, in addition to canonical autophagy, Bcl-2 can regulate non-canonical autophagy, since knockdown of Bcl-2 activity from the Bcl-2 inhibitor Z18 induces autophagy that is unaffected by Beclin 1 and phosphatidyl inositol 3-kinase inhibition [74]

By icmt24

There is some recent evidence that, in addition to canonical autophagy, Bcl-2 can regulate non-canonical autophagy, since knockdown of Bcl-2 activity from the Bcl-2 inhibitor Z18 induces autophagy that is unaffected by Beclin 1 and…