SGLT2 inhibitors offer a new addition to hyperfiltration control
SGLT2 inhibitors offer a new addition to hyperfiltration control. of Rapamycin (mTOR). Activated mTOR induces the synthesis of matrix proteins responsible for basement membrane thickening and mesangial matrix build up. In addition, mTOR is definitely incriminated in renal fibrosis. In addition, mTOR stimulates infiltration of the kidney interstitium by macrophages through monocyte chemoattractant protein-1 (MCP-1)…