Potential interrelation of nitric oxide (NO) generation by inducible nitric oxide synthase (iNOS) and by asymmetric dimethylarginine (ADMA) and the pathophysiology of sepsis
Potential interrelation of nitric oxide (NO) generation by inducible nitric oxide synthase (iNOS) and by asymmetric dimethylarginine (ADMA) and the pathophysiology of sepsis. septic shock. Being an inhibitor of NO production, ADMA may at least partly counteract pathological hypotension, but at the same time may impair the NO-dependent host defence. A mechanism is proposed by…