The GSK3, GS, and -catenin signals were normalized by GAPDH
The GSK3, GS, and -catenin signals were normalized by GAPDH. Dyrk1A-mediated phosphorylation in the Thr356 residue inhibits GSK3 activity. Dyrk1A transgenic (TG) mice are low fat and resistant to diet-induced weight problems because of low fat mass, which ultimately shows an inverse relationship with the result of GSK3 on weight problems. This total result suggests…