Originally, polyclonal ACPAs have already been proven to activate macrophages and promote production of proinflammatory cytokines via an immune-complex (IC)-mediated mechanism reliant on the Fc receptors and activation from the TLR4-MyD88 pathway
Originally, polyclonal ACPAs have already been proven to activate macrophages and promote production of proinflammatory cytokines via an immune-complex (IC)-mediated mechanism reliant on the Fc receptors and activation from the TLR4-MyD88 pathway.12C15 Incorporation of RF in the ACPA-IC augmented this effect.16 17 on Later, monoclonal ACPAs generated from either DY131 the bloodstream or the synovial…